To promote awareness of brain tumors and the need for effective treatments.
BTFC Awarded Grants
- The blood brain barrier is an interface between the brain and the bloodstream that is well known for its ability to limit the entry of chemotherapy drugs into both the normal brain and even into portions of brain tumors. Drugs that are unable to cross this barrier cannot be used to treat brain tumors. So, the ability to find out if a drug can cross this barrier would be very useful. One of the most important ways that this barrier prevents drug entry is through the activity of certain proteins that actively remove chemotherapy drugs from brain tumors by pumping them back into the bloodstream. The focus of this work is to develop and test a model that can predict which drugs will be excluded from the brain by these pumps. This will allow an easy prediction of which chemotherapy drugs penetrate into brain tumors and are more likely to be effective in people. In this way, this model will speed up the process of finding effective drugs against brain tumors.Dr. Sani Kizilbash - Crossing the Blood Brain Barrier2012
- This study looks at the effects of radiation treatments on neuro cognitive decline. There is a similarity between Alzheimer’s dementia and Radiation induced dementia. A genetic marker, Apolipoprotein E (Apo E) in its various forms can suggest a patient’s predisposition of developing early Alzheimer’s dementia. By testing the blood of brain tumor patients for this Apo E and then performing neuro cognitive testing at different time points it’s the hope of the study to determine which patients might be more at risk of side effects from radiation therapy.Dr. Jane Cerhan - Quality of Life (QOL) study2012
- Autophagy is the stage where the tumor starts to feed off itself making it necessary to have a blood supply to stay alive. This study tests drugs that stop autophagy and combine with standard chemo to inhibit growth and help to kill off cancer cells.Dr. Richard Bram - Autophagy Inhibition for Medulloblastoma2011
- STAT3 proteins seem to be critical for the growth of the tumor and also important in shielding the tumor from responding to chemo. The goal of this study is to see if blocking the STAT3 protein it will block the growth of the tumor. BTFC awarded Dr. Daniels a renewal grant in 2011.Dr. David Daniels - STAT3 Study2010
- This is an imaging study using PET scans to line up with MRI’s pre surgery. This allows the surgeon to biopsy spots that light up on the PET scan to see if this is tumor or not. This will be very helpful in patients who receive radiation therapy. BTFC awarded Dr. Laack a renewal grant in 2010.Dr. Nadia Laack - FDOPA study2009