Crossing the Blood Brain Barrier (2012)
Led by: Dr. Sani Kizilbash
Abstract: The blood brain barrier is an interface between the brain and the bloodstream that is well known for its ability to limit the entry of chemotherapy drugs into both the normal brain and even into portions of brain tumors. Drugs that are unable to cross this barrier cannot be used to treat brain tumors. So, the ability to find out if a drug can cross this barrier would be very useful. One of the most important ways that this barrier prevents drug entry is through the activity of certain proteins that actively remove chemotherapy drugs from brain tumors by pumping them back into the bloodstream. The focus of this work is to develop and test a model that can predict which drugs will be excluded from the brain by these pumps. This will allow an easy prediction of which chemotherapy drugs penetrate into brain tumors and are more likely to be effective in people. In this way, this model will speed up the process of finding effective drugs against brain tumors.