Myeloid-derived suppressors (2013)

Led by: Dr. Ian Parney

Abstract: Immunotherapies like vaccines that stimulate the immune system to fight cancer hold great promise for malignant brain tumors. Unfortunately, brain tumors have ways to fight back against the immune system that can limit the benefit of immunotherapy.  In this study, we are examining how brain tumors can cause normal white blood cells called monocytes to become cells called myeloid-derived suppressors that turn off the immune system. We hope this will lead to new treatments to reverse these immune suppressing effects and make immunotherapies more effective.